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         Daily Blog - Tiger Software

                         September 5, 2007

  How To Find A BioTech Boomer Early On 
                   Part 1 of a 10 part series.

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People have asked me to write a Daily Blog.  
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    have to wait and see.  As, I see it, a blog is a
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9/5/2007    How To Find A BioTech Boomer Early On 
      The Beginning of A Multi-Part Series on Biotech Investing.    

                       As "baby boomers" age and retire, some biotechs will surely boom, too.  In the US there are more
              than 75 million baby boomers. 

                      Biotechs are manic.  They seem to fluctuate widely.  There are long periods during which few
               of them advance and most drift lower.  And there are exciting periods, often spurred on by a well
               publicized breakthrough and a block-buster drug.  After AMGEN discovered and got FDA approval for
               two blockbuster drugs, Neopogen and Epogen, in early 1991, other biotech stocks went wild.

                     The 20-year chart of Fidelity's Biotech (FBIOX) fund is shown below.  In it you can see all of the
               advance in prices came in 2 important surges: 1989-1992 and 1998-2000.  Technically speaking,
               a chartist would have bought early in 1990, never mind that there were two steep general market
               declines that year, and sold when Amgen shareholders met in 1991 to celebrate their good fortune.
               His profits would have been 300% in a year and a half.   The breakout by FBIOX in December 1998
              was the second point of important entry. Early in 2000, just as Greenspan was reappointed by Clinton,
              FBIOX had achieved a triple again.   Except for those two episodes that took up less than 3 years
              in the 20 year period, FBIOX was either going sidewise or down.   The FBIOX seems to go into
              dormant periods lasting 7 or 8 year.  So a new move up is due.  One more thing, you can bet on:
              the Democrats, if they take the White House in 2009, are going to increase public funding of stem
              cell research.  This will bring publicity to these companies' prospects and overseas' biotech
              companies' successes.  I would not wait until November 2009 to buy a biotech.  I would anticipate
              this development.

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                  Now as we look at the Tiger chart of FBIOX below we see it is approaching a series
           past peaks at 69.  A breakout above that level would be bullish.  Not as bullish as a
          breakout into all-time high territory, but still very bullish.  The Tiger chart of FBIOX
          (Fidelity Biotech) shows that a breakout has already taken place when FBIOX is
          compared with the DJI.

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                 I have observed that Biotechs are often a place where hot money goes when it
          is starting to get nervous about the market.  The collapse of many housing and mortgage
          stocks has cast a pall on may sectors of the stock market.  But tech stocks, and biotechs
          are starting to get a play.   How do we decide which stocks to buy?  That is the subject of
          the next few blogs. 

                One of the easiest approaches is to simply see what stocks Fidelity has invested
          in.  Yahoo reports their 10 biggest holdings, as last reported.  Right now these are their

Company Symbol % Assets YTD Return %
AMGEN AMGN 20.68 -21.33

                  Tiger lets us easily graph these stocks.

                            AMGN -  Amgen  ... On Buy... Top System's Gain = 58.3%

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           DNA -  Genentech   ... On Buy... Top System's Gain = 56.2%
      Decisive breakout past blue 50-day ma.

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                  BIIB -   ... On Buy... Top System's Gain = 50.1% 
              Strongest of these.  Shows most blue from Tiger's Accumulation Index.

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                      GILD -  Gilead Sciences ... On Buy... Top System's Gain = 50.1%
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                     CELG -  Celgene  ... On Buy... Top System's Gain = 58.1%
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                    CEPH -  Cephalon  ... On Buy... Top System's Gain = 82.6%
            Watch - back to the resistance of its nest key mvg. avgs. other than 50-day ma

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              ALXN -  Alexion  ... On Buy... Top System's Gain = 106.2%
       Powerful up move today!

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                  VRTX -  Vertex Pharm  ... On Buy... Top System's Gain = 104.6%wpe15.jpg (65550 bytes)

                PDLI -  Protein Design Labs  ... On Buy... Top System's Gain = 149.5%
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                     To Be continued..  This is the first of a long series on Biotech Investments



                    Biotech Jokes,  Cartoons and Tidbits To Talk about.

               Genetics Savings and Clone, charges $1000 to collect and cryogenically store cells from a family cat or
                   dog, and $250,000 to clone it.

                                      Gene Patents Prevent Research

                   "A few years ago, UCLA geneticist Wayne Grody was working hard to help deaf children. Grody
                   was conducting clinical tests on Connexin 26, a human gene linked to deafness, hoping it would lead to
                   more effective treatment for kids. Then one day he received a letter from Athena Diagnostics, a
                   Massachusetts-based biotechnology company. Grody says the letter informed him that Athena owned
                   a patent for the Connexin 26 gene -- and he could no longer perform tests on it himself. Instead, he would
                   have to pay thousands of dollars up-front and send future gene samples to Athena for testing. He had no
                   choice. "I had to stop," Grody says. "The cost was out of sight." The clinical tests ground to a halt."

                           --   Source: Michael Crowley, "They Own Your Body" Readers' Digest, August 2006 --

                                                    Biotech Personals


I've been single-stranded too long! Lonely ATGCATG would like to pair up
with congenial TACGTAC.

Menage a trois! Ligand seeks two receptors into binding and mutual
phosphorylation. Let's get together and transduce some signals.

Some dates have called me a promotor. Others have referred to me as a real
operator. Personally, I think I'm just a cute piece of DNA who is still
looking for that special transcription factor to help me unwind.

Highly sensitive, orally active small molecule seeks stable well-structured
receptor who knows size isn't everything.

There must be a rational way to meet a date! I'm tired of hanging out in
those molecular diversity bars, hoping to randomly bump into the right
peptide. I want a molecule that will fit right into my active site and
really turn me on. I'll send you my crystal structure if you send me

Gene therapy graduate. After years of producing nothing but gibberish, I've
shed my exons and am ready to express my introns. All I need is a cute
vector to introduce me to the right host.

My RNA, I'm sorry I misread your UAAUAAUAA and inserted three tyrosines
when you repeatedly asked me to stop. Something got lost in the
translation. Please forgive me.

Naked DNA with sticky ends seeks kanamycin-resistant plasmid. EcoR1 sites

Uninhibited virus seeks reason to make me shed my coat protein.

This very selective oliogonucleotide has been probing for just the right
target for long term hybridization.

Mature cell seeks same who still enjoys cycling and won't go apoptotic on
me. Let's fight senescence together!

I'm a prolific progenitor with great potential for growth and self-renewal.
Call me if you're a potent hematopoietic factor who still believes in
endless nights of colony stimulation.

I don't always express myself on the surface, but I'm looking for a signal
that you appreciate my complexity. Send me the right message that will
penetrate my membranes, turn on my protein expression and release my
potential energy.



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