Biotechs over $5 that are up 220% or more
               
   13  declined     
                     5 rose. 
  

                               The research I've done on the way the strongest stocks topped
                               out in 1999-2000 shows several things:

                                
  1) Weekly OBV non-confirmations of new highs gave the
                                   most timely Sells on these stocks.  I will be posting weekly
                                   data on all the strongest biotechs on our data page.  It
                                   will be included in the regularly weekly data.

                                   2) Many of the 1999-2000 stocks were up 8x-10x their 12-month
                                   lows.

                                   3) 25% were more than 48% above their 21-day ma.

                                   4) Closing Power trend-breaks in the very strongest stocks
                                   was the most common way one could have know that a
                                   top had been made.

                                 
5) In the daily charts, Closing Power NCs and OBV NCs occurred
                                   at 1/2 the tops.

                                   6) Head and shoulders in the daily charts appreared In 1/4 of
                                   the 1999-2000 super stocks as  they were topping out.

                                   7) False breakouts occurred in 1/4 of the these stocks.

                                   8) The declines that resulted were swift and punishing to the
                                   longs who ignored them.  30%-50% declines within three months
                                   were the norm.  Some were even more severe.     

                             
  Biotechs over $5 that are up 220% or more        

                                                   1/13/2014      1/17/2014   One Day    1/22/2013-1/17/2014
                                                                                           Pct Gain             Pct Gain
                                       --------------------------------------------------------------
                                        ICPT       445.83           292.88        +5%              +756%    pulled back to top of gap.
                             ------->BCRX        10.51            10.80        
 -----                +562%     channel breakout  
                                            13.53 is 5-year high - OBV confirming.
                                           
BioCryst Pharmaceuticals  40 employees Durham, NC    http://www.biocryst.com
                                                 -    develops novel drugs that block key enzymes involved in the pathogenesis of diseases.
                                                 -    in Phase III clinical trials for acute influenza;
                              ------>ARWR    12.32              12.31        
-3%                +472%      on channel breakout run
                                             All-time high.  OBV is confirming.
                                            
Arrowhead Research Corp. 54 employees http://www.arrowheadresearch.com
                                             ARC-520, an RNAi-based therapeutic that has completed a Phase 1 clinical trial for the
                                              treatment of chronic hepatitis B virus (HBV) infection; and
                                              Adipotide, which is in Phase I clinical trial for the treatment for obesity.

 
                                       IDRA        5.03                4.34          
-3%                 +478%    at rising 21-dma
                             ------>PBYI       112.26           125.81          +3%                 +414%     B10/B12/B20/B24 run
                                                 All-time high.   OBV is confirming. 
                                               
http://www.pumabiotechnology.com    49 employees LA,CA
                                         Engages in the acquisition, development, and licensing of products for the treatment of various                                             forms of cancer. Its drug candidates include PB272 (neratinib (oral)) for the treatment of
                                         advanced breast cancer patients and non-small cell lung cancer patients; and PB272
                                         (neratinib (intravenous)) for the treatment of advanced cancer patients

                                      ACAD     23.32               24,04         
-1%              +323%      stalled at 65-dma
                                               30 is 5-year high. OBV is weakening.
                                       SNMX   5.69                   7.30         +3%               +322%     channel breakout run
                                               8 is 5-year high                                              .
                                       NPSP      35.0                  35.67        -1%                  +290%    double top?   IP21= .45
                                             
triangle pattern old highs.  Ususally bullish
                                              OBV is lagging.
                                       GALE    7.24                    7.00       
  -7%                 +286%    Heavy red distribution. CP weak.                                                 OBV H/S pattern.                                      
                                       ALNY                              87.36    
  -1%                +273%    gap held and reversal.
                                             5-year high.  Wkly OBV is confirming. .
                                       ANAC     17.52                19.38       +2%                +270%   
                                             Wkly OBV confirming.  Both UP condition.  
                                       CLVS     76.26                  72.90      
-3%                +252%   at 7-month resistance
                                             Resistance is 80-86 OBV is lagging.
                                       CLDX    25.66                28.32      
-1%          +279%   trying to resume uptrend,. 39 = 12m high
                                            
Weekly OBV is lagging
                                        ISIS       47.22                 47.14      
-2%                 +241%    at top of price channel IP21 = .63
                                            OBV is lagging.                                       
                                        CYTR    7.47                    7.04        +1%                    +228%   
Heavy red distribution. CP weak.
                                       --------------------------------------------------------------------------------------------------------------
                                                                             New Bios up over 220%
                                       --------------------------------------------------------------------------------------------------------------     
                             -
------> ANIK                              37.39        -5%                     +248%     at resistance-39. Watch.
                                            Weekly OBV is confirming.  CP is lagging. 

                                             106 employees - Bedford, MA  http://www.anikatherapeutics.com
                                             Products for tissue protection, healing, and repair. Its products are based
                                             on hyaluronic acid (HA), a naturally occurring biocompatible polymer found in the body.
                                       VNDA                              13.27      -----                  +222%      at resistance-13-14.
                                             17 is 5-year high... OBV is lagging.
                                       INCY                               61.87       
-3%                  +230%    channel breakout run IP21=.299

                                              Weekly OBV has been slow to confirm
              Also interesting high IP21 Biotechs
   IP21
   .592             NBIX   19.64    +.05  78 employees SD< CA  Elagolix, a Phase III drug for endometriosis
   .403              PSTI       4.34 -.04    142 employees Israel   company?s PLX  cells function as a drug delivery platform
   .473              GEVA   96.48 +3.86  B10/B12 run.  115 employees Lexington, MASS
                                                          Sebelipase alfa, a recombinant form of human lysosomal acid lipase (LAL) is under                                                             Phase III clinical trials for the treatment of early and late onset LAL Deficiency..
   .429              NPSP     35.67 -.20    readying an explosion past 37 AI/200=154 149 employ...NJ
                                                        Natpara that is under Phase 3 clinical trial for the treatment of adult hypoparathyroidism
   .453            SGMO    19.64 -.20    AI/200=145 looks very good. Multiple Buys    Richmond, CA 84 employees
                                                           ZFP TFs) proteins that could be used to turn genes on or off.
   .429              VRTX    82.09 +1.09   resistance up to 90.
   .417            ALXN   139.71 -.10    new high AI/200=159   
   -------------------------------------------------------------------------------------------------------------------------------
                       GILD    78.4 +.50         Biggest FBIOX holding.                        

BCRX.BMP (1920054 bytes)
ARWR.BMP (1920054 bytes)
PBYI.BMP (1920054 bytes)
ANIK.BMP (1920054 bytes)
SGMO.BMP (1920054 bytes)